Eptifibatide kanggo Perawatan Sindrom Koroner Akut 188627-80-7
Detail Produk
| jeneng | Eptifibatide |
| Nomer CAS | 188627-80-7 |
| Rumus molekul | C35H49N11O9S2 |
| Bobot molekul | 831.96 |
| Nomer EINECS | 641-366-7 |
| Kapadhetan | 1,60±0,1 g/cm3 (Prediksi) |
| Kondisi panyimpenan | Disegel ing garing, simpen ing kulkas, ing ngisor -15 ° C |
sinonim
Eptifibatideacetatessalt;Eptifibatide,MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2,MPAHARGDWPC-NH2,>99%;MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2;INTEGRELIN;Eptifibatide;N6-(Aminoimi nometil)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-La-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide;MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2(DISULFIDEBRIDGE,MPA1-CYS6).
Antagonis Glikoprotein Platelet
Etifibatide (integrilin) minangka antagonis reseptor platelet glycoprotein IIb / IIIa polipeptida anyar, sing nyegah agregasi trombosit lan trombosis kanthi nyegah jalur umum pungkasan agregasi platelet. Dibandhingake karo abciximab antibodi monoklonal, eptifibatide nduweni ikatan sing luwih kuat, luwih arah lan spesifik kanggo GPIIb / IIIa amarga ana siji substitusi asam amino konservatif-lisin kanggo ngganti arginin. Mulane, kudu duwe efek terapeutik sing apik ing perawatan intervensi sindrom koroner akut. Obat antagonis reseptor platelet glikoprotein IIb/IIIa wis akeh dikembangake, lan saiki ana 3 jinis preparat sing bisa digunakake ing klinis internasional, abciximab, eptifibatide lan tirofiban. ). Ora ana pengalaman cilik babagan panggunaan antagonis reseptor glikoprotein platelet GPIIb / IIIa ing China, lan obat-obatan sing kasedhiya uga winates banget. Mung siji obat, tirofiban hydrochloride, sing ana ing pasar. Mulane, glikoprotein IIb platelet anyar dikembangake. /IIIa antagonis reseptor penting. Eptifibatide domestik minangka produk tiruan sing diprodhuksi dening Chengdu Sino Biological Products Co., Ltd.
Klasifikasi
Klasifikasi Obat Agregasi Antiplatelet
Obat agregasi antiplatelet bisa dipérang dadi telung kategori: 1. Inhibitor Cyclooxygenase-1 (COX-1), kayata aspirin. 2. Nyandhet agregasi platelet sing disebabake dening adenosin difosfat (ADP), kayata clopidogrel, prasugrel, cangrelor, ticagrelor, lan liya-liyane. komponen kimia lan ekstrak efektif saka obat tradisional Cina.
